Day Four
Program
Day 4: Thursday, October 25, 2018
Session I – Targeting Early Infection Events
This session aims to provide new information on cell-cell interactions and signaling events that are important for the early steps of HIV-1 replication and the window of opportunity for intervention. More specifically, the therapeutic potential of events associated with chemokine receptors, virus entry, viral synapses, and post-entry processes will be presented.
Chairpersons and Discussants:
George Lewis, PhD, Institute of Human Virology, University of Maryland School of Medicine, US
Anthony Devico, PhD, Institute of Human Virology, University of Maryland School of Medicine, US
Schedule:
9:00 AM
Presentation Title: Quaternary Contact Improves the Potency of Broadly Neutralizing Antibodies to the CD4-Binding Site of HIV-1
Speaker: Paolo Lusso, MD, PhD, National Institute of Allergy and Infectious Diseases, US
9:25 AM
Presentation Title: Viral Fitness Costs and Benefits of Disrupting the Host Cell Actin Cytoskeleton in Mucosal HIV-infection
Speaker: Thorsten Mempel MD PhD, Harvard University, US
9:50 AM
Presentation Title: HIV-1 cell-to-cell infection during acute infection and resistance to neutralizing antibodies
Speaker: Benjamin Chen, MD PhD, Mount Sinai School of Medicine, US
10:15 AM
Presentation Title: Distinct Chromosomal Positions of Intact HIV-1 proviruses
Speaker: Mathias Lichterfeld, MD, Ragon Institute of MGH, MIT and Harvard, US
Coffee Break, 10:40 AM - 11:00 AM
11:00 AM
Presentation Title: Nonhuman Primate Models in the Study of Early Event in AIDS Virus Infection
Speaker: Jeff Lifson, MD, National Cancer Institute, US
11:25 AM
Presentation Title: Early treatment initiation in children with perinatal HIV infection: Challenges and Opportunities
Speaker: Savita Pahwa, MD, University of Miami Miller School of Medicine, US
11:50 AM
Presentation Title: Long-range allosteric effects induced by Tax–HLA-A2 binding to an anti-HTLV-1 TCR: Implications for early T cell signaling
Speaker: Roy Mariuzza, Institute for Bioscience and Biotechnology Research, University of Maryland, US
Lunch Break, 12:15 PM – 1:20 PM
Session J - Approaches to Eliminate Persistent Viruses
Persistent viral infections affect approximately one in six of all living human beings. Mechanisms of chronicity involve circumventing host immune defense mechanisms, hence the current therapeutic goals have remained focused at long term suppression for many of the common persistent viral infections, such as HIV and HBV. Recently, there is emergent enthusiasm in developing antiviral and host immune targeting agents to achieve a functional cure for both HIV and HBV infections. These agents are currently being evaluated in early phase clinical trials and, if safe and effective, could transform how we treat chronic infections and impact lives of millions of patients worldwide in a positive manner.
Chairpersons and Discussants:
Shyamasundaran Kottilil, MD, PhD, Institute of Human Virology, University of Maryland School of Medicine, US
Henry Masur, MD, National Institutes of Health, US
Schedule:
1:25 PM
Opening Remarks
Shyamasundaran Kottilil, MD, PhD, Institute of Human Virology, University of Maryland School of Medicine, US
1:35 PM
Presentation Title: Diagnosis and Treatment of HCV in the VA Healthcare System
Speaker: Timothy Morgan, MD, National Hepatitis C Resource Center, US
2:00 PM
Presentation Title: Approaches to Eliminate Persistent Viruses
Speaker: Eleanor Wilson, MD, Institute of Human Virology, University of Maryland School of Medicine, US
2:25 PM
Presentation Title: The International Coalition to Eliminate Hepatitis B (ICE-HBV)
Speaker: Peter Revill, PhD, Doherty Institute, Australia
2:50 PM
Presentation Title: Towards a Functional Cure for HBV: An Industry Perspectcive
Speaker: Anuj Gaggar, MD, PhD, Gilead Sciences, Inc., US
Coffee Break, 3:15 PM - 3:35 PM
3:35 PM
Presentation Title: Novel antiviral targets for HBV elimination
Speaker: Claudia Hawkins, MD, Northwestern University, US
4:00 PM
Presentation Title: Immune correlates of HBV cure
Speaker: Bhawna Poonia, PhD, Institute of Human Virology, University of Maryland School of Medicine, US
4:25 PM
Presentation Title: Interrogating the immunologic and microbial cervical microenvironment in HPV infection
Speaker: Patti Gravitt, PhD, George Washingtion University, US
4:50 PM
Presentation Title: Role of DNA Methylation in Prediction of Human Papillomavirus Persistence and Carcinogenesis
Speaker: Attila Lorincz, PhD, Queen Maryland University of London, United Kingdom
Meeting Adjourns 5:15 PM