Day One
Program
Day 1: Monday, October 22, 2018
Session A – The 40th Anniversary of the Discovery of the First Human Retrovirus, HTLV
In 1978, discovery of HTLV, the first virus shown to directly cause a human cancer, was reported at a scientific conference and published in 1980 by Dr. Robert Gallo's group. To mark the 40th anniversary of this important scientific breakthrough, an opening session is devoted to a retrospective of HTLV-1 research, the current global state of the virus, and new frontiers in HTLV-1 studies.
Chairpersons and Discussants:
Robert Gallo, MD, Institute of Human Virology, University of Maryland School of Medicine, US
Yutaka Tagaya, MD, PhD, Institute of Human Virology, University of Maryland School of Medicine, US
Schedule:
9:00 AM
Opening Comments
Robert Gallo, MD, Institute of Human Virology, University of Maryland School of Medicine, US
9:10 AM
Presentation Title: The human leukemia virus - HTLV-1 - persistence and pathogenesis
Speaker: Charles Bangham, PhD, Imperial College London, UK
9:40 AM
Presentation Title: Do biological differences exist between HTLV-1A and HTLV-1C?
Speaker: Genoveffa Franchini, MD, National Cancer Institute, US
10:05 AM
Presentation Title: Epidemiology and Original of HTLV-1 and Related Viruses Infection
Speaker: Antoin Gessain, MD, PhD, Institut Pasteur, France
Coffee Break, 10:30 AM - 11:00 AM
11:00 AM
Presentation Title: Tracing the intracellular jouney of HTLV-1 HBV during infection: From asymptomatic carriers to HAM/TSP ending to ATL: A one-way ticket?
Speaker: Roberto Accolla, University of Insubria, Italy
11:25 AM
Presentation Title: Role of fibroblasts in HTLV-1-mediated lymphomagenesis
Speaker: Luigi Chieco-Bianchi, University of Padova, Italy
Lunch Break, 11:50 AM – 1:20 PM
1:20 PM
Presentation Title: Strategy and pathogenesis of human T-cell leukemia virus type 1
Speaker: Masao Matsuoka, MD PhD, Kyoto University, Japan
1:45 PM
Presentation Title: A general description of the HTLV-1 Cohort at the Institute of Tropical Medicine Alexander von Humboldt (1989-2015)
Speaker: Eduardo Gotuzzo, MD, Universidad Peruana Cayetano Heredia, Peru
2:05 PM
Presentation Title: HTLV-1/BLV genomic approaches to understanding ATL
Speaker: Anne Van den Broeke, Institute of Jules Bordet, Universite Libre de Bruxelles, Belgium
2:30 PM
Presentation Title: A novel multi-cytokine inhibitory strategy in treating HTLV-1 diseases
Speaker: Yutaka Tagaya, MD, PhD, Institute of Human Virology, University of Maryland School of Medicine, US
Coffee Break, 2:55 PM – 3:25 PM
Session B – Exosomes in Health and Disease
Exosomes, small extracellular vesicles released by most cells of the human body, are essential for healthy physiological conditions; however under some circumstances they act to potentiate cellular stress and damage, affecting viral infection. Exosomes carry various cellular lipids, proteins, and small RNAs that can change metabolism of the recipient cells and are thought to constitute a system of cell–cell communications. Cell-to-cell communication and the transmission of disease states has potential implications for drug discovery. Areas of emphasis in this session will range from cytokines in extracellular vesicles (EVs) to mechanisms of EVs in viral transmission.
Chairpersons and Discussants:
Leonid Margolis, PhD, National Institute of Child Health and Human Development, US
Robert Gallo, MD, Institute of Human Virology, University of Maryland School of Medicine, US
Schedule:
3:25 PM
Presentation Title: Placental exosomes in maternal-placental-fetal communication and viral resistance
Speaker: Yoel Sadovsky, MD, Magee-Womens Research, University of Pittsburgh, US
3:50 PM
Presentation Title: Exosomal protein signatures: mechanistic insights and biomarker potential
Speaker: Ayuko Hoshino, Weill Cornell Medical College. US
4:15 PM
Presentation Title: Not All Soluble Cytokines are Soluble: Cytokines in Extracellular Vesicles Mediate Cell-Cell Communications
Speaker: Leonid Margolis, PhD, National Institute of Child Health and Human Development, US
4:40 PM
Presentation Title: Presence of HIV-1 RNA in Extracellular Vesicles from HIV-1 cART-treated Cells
Speaker: Fatah Kashanchi, PhD, George Mason University, US
5:05 PM
Presentation Title: Extracellular vesicle as advance forces in cancer
Speaker: Xandra Breakefield, PhD, Massachusetts General Hospital, US
Opening Reception, 5:30 PM - 7:30 PM