Structural Biology & Molecular Biophysics

Taking advantage of IHV’s longstanding expertise in analyzing proteins, peptides and their interactions quantitatively and at atomic level resolution, IHV investigators in the Division of Infectious Agents and Cancer have extensive expertise in protein and peptide structure determination by:

• X-ray
• crystallography
• nuclear magnetic resonance (NMR)
• circular dichroism (CD)

This is also determined as

• molecular interaction analysis by surface plasmon resonance (SPR)
• isothermal titration calorimetry (ITC)
• fluorescence polarization (FP)
• fluorescence resonance energy transfer (FRET)
• analytical ultracentrifugation (AUC)

These studies are critical to defining the molecular bases of pathogenesis and to rationalizing therapeutic development for the entire spectrum of diseases on which IHV researchers work.