Day Two
Program
Day 2: Tuesday, October 24, 2017
Session D – Immunology and Viral Pathogenesis
Innate and adaptive immune responses play a role in controlling viral replication. Yet, immune dysfunction is common in HIV-infected individuals and the virus has developed multiple strategies to evade host defenses. New findings on the pathogenesis of HIV and other viral infections and their implications in for treatment strategies will be presented.
Chairpersons and Discussants:
Warner Greene, MD, PhD, Gladstone Institutes
Anthony Devico, PhD, Institute of Human Virology
Schedule:
8:30 AM
Presentation Title: The role of stress agents in immunization against HIV-1 infection
and eliciting CD4+ memory stem cells
Speaker: Thomas Lehner, MD, Kings College London
8:55 AM
Presentation Title: Immune-based interventions for HIV cure: lessons from NHP models
Speaker: Guido Silvestri, MD, Emory University
9:20 AM
Presentation Title: HIV Cure: Time to Rethink the “Shock and Kill” Strategy?
Speaker: John Mellors, MD, University of Pittsburgh
9:45 AM
Presentation Title: Clonal proliferation of CD4 T cells encoding intact HIV-1
Speaker: Mathias Lichterfeld, MD, Ragon Institute
Coffee Break, 10:10 AM - 10:25 AM
10:25 AM
Presentation Title: Reversible HIV-1 Latency Induced in Primary Human Monocyte-Derived Macrophages by Repeated M1 Polarization
Speaker: Guido Poli, MD, Vita-Salute San Raffaele University
10:50 AM
Presentation Title: Chromatin functional states correlate with the reversal of latently HIV-1infected primary CD4+ T cells.
Speaker: Eric Verdin, MD, The Buck Institute
11:15 AM
Presentation Title: HIV Env trimer immunogen design and modification to elicit neutralizing antibodies
Speaker: Richard Wyatt, PhD, Scripps Research Institute
11:40 AM
Presentation Title: Innate-primed alternative signaling pathways enhance functional mucosal
mobilization of memory-like NK cells in HIV/SIV infection
Early-stage Speaker: Keith Reeves, PhD, Harvard Medical School
Lunch, 12:05 PM – 1:20 PM
Session D – Immunology and Viral Pathogenesis (continued)
Chairpersons and Discussants:
Anders Vahlne, MD, PhD, Karolinska Institute
Alan Schmaljohn, PhD, University of Maryland School of Medicine
1:20 PM
Presentation Title: Defining a Potent New Class of Latency Reversing Agents Devoid of Toxicity and Detrimental Cell Activation That Enhance CTL/NK Cell Killing
Speaker: Warner Greene, MD, PhD, Gladstone Institutes
1:45 PM
Presentation Title: Combination of CRISPR-Cas9 and Long Acting Slow Effective Release
Antiretroviral Therapy Eliminates HIV-1 Infection in Humanized Mice
Speaker: Howard Gendelman, MD, University of Nebraska Medical Center
2:10 PM
Presentation Title: Influence of age on immune response to influenza vaccination in virologically suppressed HIV infected persons
Speaker: Savita Pahwa, MD, University of Miami
Session E – Public Health Science and Responses - From Local to Global
As the world around us is becoming progressively interconnected and complex, addressing emerging viral infections and HIV through: 1) surveillance; 2) applied research; 3) infrastructure and training; and 4) prevention is important for epidemic control. This session focuses on achieving these objectives locally and globally.
Chairpersons and Discussants:
Erica Ollmann Saphire, PhD, Scripps Research Institute
Kathleen Neuzil, MD, MPH, Center for Vaccine Development, Institute of Global Health, University of Maryland School of Medicine
Schedule:
2:35 PM
Presentation Title: Infectious Disease - Public Health Response
Speaker: Boris Lushniak, MD, MPHD, Dean, UMCP school of Public Health
3:00 PM
Presentation Title: Policy, Practice and Science in Nigeria: Implementing Evidence Based Research for HIV Programming in Nigeria
Speaker: The Honorable Issac Adewole, MD, The Federal Minister of Health, Nigeria
3:25 PM
Presentation Title: Global Health Security – Why is it important?
Speaker: Kashef Ijaz, MD, MPh, Centers for Disease Control and Prevention
3:50 PM
Presentation Title: Virus genomes reveal factors that spread and sustain the Ebola epidemic
Speaker: Early-stage: Gytis Dudas, PhD, Fred Hutchinson Cancer Research Center
Coffee Break, 4:15 PM - 4:30 PM
Session F – Cancer and Stem Cells
Cancer stem cells have now been recognized in a wide variety of human tumors. The existence of cancer stem cells poses both tremendous challenges and tantalizing potential for our ability to successfully combat cancer. This session aims to bring together scientists who are interested in better understanding the mechanisms by which cancer stem cells contribute to tumor heterogeneity, self-renewal and drug resistance. Areas of emphasis will be intercellular communication and stem cell aging influence on cancer initiation and progression. Cellular context and microenvironment establish the tumor niche and shape the interaction of the tumor with the immune system.
Chairpersons and Discussants:
Leonid Margolis, PhD, National Institute of Child Health and Human Development
Guido Poli, MD, Vita-Salute San Raffaele University
Schedule:
4:30 PM
Presentation Title: Regulation of Leukemogenesis by the Bone Marrow Niche
Speaker: Stavroula Kousteni, PhD, Columbia University
4:55 PM
Presentation Title: Inflammation and immune modulation: tackling age-related stem cell dysfunction
Speaker: Heinrich Jasper, PhD, Buck Institute for Research on Aging
5:20 PM
Presentation Title: Targeting Aberrant Transcription in Pre-Cancerous Stem Cells
Speaker: Ulrich G. Steidl, MD, PhD, Albert Einstein College of Medicine
5:45 PM
Presentation Title: Decoding the regulatory networks of Leukemic Stem Cells through Ubiquitylation
Early-stage Speaker: Chozha Rathinam, PhD, Institute of Human Virology